"Relative Strengths of NH\u00B7\u00B7O and CH\u00B7\u00B7O Hydrogen Bonds between Polypeptide ChainSegments" . . . "Correlated ab initio calculations are used to compare the energetics when the CH and NH groups of themodel dipeptide CHONHCH2CONH2 are each allowed to form a H-bond with the proton acceptor O of apeptide group. When the dipeptide is in its C7 conformation, the NH\u00B7\u00B7O H-bond energy is found to be 7.4kcal/mol, as compared to only 2.8 kcal/mol for the CH\u00B7\u00B7O interaction. On the other hand, the situation reverses,and the CH\u00B7\u00B7O H-bond becomes stronger than NH\u00B7\u00B7O, when the dipeptide adopts a C5 structure. This reversalis important as C5 is nearly equal in stability to C7 for the dipeptide, and is representative of the commonlyobserved \u03B2-sheet structure in a protein. Immersing the dipeptide\u2212peptide pair in a model solvent weakensboth sorts of H-bonds, and in a fairly uniform manner. Consequently, the trends observed in the in vacuosituation retain their validity in either aqueous solution or the protein interior. Likewise, the desolvationpenalty, suffered by removing a H-bonded complex from water and placing it in the less polar interior of aprotein, is quite similar for the NH\u00B7\u00B7O and CH\u00B7\u00B7O bonds." . . . . . . . . .