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| - Identification of Chiral Selectors from a200-Member Parallel Combinatorial Library
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| - Selection of chiral selectors for the resolution of racemicN-(1-naphthyl)leucine ester 1 was studied with a 200-member parallel library prepared on polymeric synthesisresin. Through this study, the library screening proceduredeveloped previously is improved and other pertinentissues concerning the screening process are also addressed. The equilibration time required for screening isreduced from 24 h to ∼3 h. Excellent correlation of theoutcome between the resin batch equilibration experimentand chromatographic separation is further demonstrated.It is also demonstrated that selectors with separationfactors as low as 1.4 could be identified by this batchscreening process. In addition, a great deal of informationregarding enantioselective interactions was obtained inthis parallel library study. Such information should proveuseful in improving future library designs.
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