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À propos de : Catalytic Asymmetric Total Syntheses of Quinine and Quinidine        

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  • Catalytic Asymmetric Total Syntheses of Quinine and Quinidine
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  • The catalytic, asymmetric syntheses of quinine and quinidine were achieved in 16 steps. The recently developed salen(Al)-catalyzed enantioselective Michael addition of methyl cyanoacetate served to set the crucial C4 stereocenter in 92% ee, and a late-stage asymmetric dihydroxylation was used to differentiate the common intermediate and access the two desired diastereomeric products with high selectivity.
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