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À propos de : Enantioselective Friedel−Crafts Alkylations with BenzoylhydrazonesPromoted by a Simple Strained Silacycle Reagent        

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  • Enantioselective Friedel−Crafts Alkylations with BenzoylhydrazonesPromoted by a Simple Strained Silacycle Reagent
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  • The enantioselective Friedel−Crafts reaction of electron-rich arenes and heteroarenes with the benzoylhydrazone of isopropyl glyoxylate mediated by a simple chiral silane Lewis acid is described. The reactions are highly practical, as demonstrated by a larger scale (5 g of the hydrazone) reaction in which the recovery of the pseudoephedrine in 99% yield was achieved. A simple model is advanced to explain the observed enantioselectivity.
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