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À propos de : Metabolic Coupling of Dehydration and Decarboxylation in the Curacin APathway: Functional Identification of a Mechanistically Diverse Enzyme Pair        

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  • Metabolic Coupling of Dehydration and Decarboxylation in the Curacin APathway: Functional Identification of a Mechanistically Diverse Enzyme Pair
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  • This study describes the functional identification of a pair of mechanistically diverse enzymes that catalyze the successive dehydration (CurE ECH1) and decarboxylation (CurF ECH2) of (S)-HMG-ACP to generate a 3-methylcrotonyl-ACP intermediate, the presumed precursor of the cyclopropyl ring in curacin A. The reactions catalyzed by ECH1 and ECH2 are found in a broad cross-section of microbial natural product gene clusters and participate in the introduction of carbon chain branch points and functional group diversity as key steps in the HMG-CoA synthase mediated addition of C-2 from acetate to the β-carbonyl group of polyketide chains.
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