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| - Urinary and Biliary Metabolic Patterns of Chlorothalonil inGerm-Free and Conventional Rats
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| - The metabolic fate of chlorothalonil, a broad spectrum fungicide that is known to be metabolizedvia glutathione conjugation, was examined through the analysis of urine and bile metabolites. Therole of digestive microflora in the metabolism of chlorothalonil was assessed by comparing themetabolic patterns in germ-free and conventional rats. Low urinary and biliary excretion ofradioactivity was observed in both conventional and germ-free rats. However, the urinary excretionof radioactivity was higher in conventional than in germ-free rats. Radio-HPLC analysis of urineand bile showed a complex metabolic profile in both conventional and germ-free rats. Methylthiometabolites of chlorothalonil were determined in ethyl acetate extracts of urine and bile ofconventional and germ-free rats. These metabolites were excreted in a higher amount in the urineof conventional rats than in the urine of germ-free rats. This study shows the complexity ofchlorothalonil metabolism and the role of the digestive microflora in chlorothalonil metabolism. Keywords: Chlorothalonil; metabolism; germ-free rats; glutathione conjugation; thiol metabolites
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