| Abstract
| - The isotopically labeled compounds [5,6-2H2]-(Z)-1,5-octadien-3-one (d-I) and [1-2H1;2,2-2H1;1]-1-octen-3-one (d-II), as well as the unlabeled reference compound (Z)-1,5-octadien-3-one (I) were preparedby improved synthesis procedures. Labeling position, chemical purity, and isotopic distribution ofthe compounds were characterized by various MS and NMR techniques. These molecules are usedas internal standards in quantification experiments based on isotope dilution assay. The newlyprepared compound d-II was synthesized in a simple two-step procedure, and formation of the mainisotopomers was studied in model systems. Keywords: Synthesis; isotope labeling; deuteration; flavor compounds; lipid degradation products;[1-2H1;2,2-2H1;1]-1-octen-3-one; [5,6-2H2]-(Z)-1,5-octadien-3-one; NMR; GC/MS; isotope dilution assay(IDA)
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