| Abstract
| - Three new diterpenoids belonging to the clerodane (2−3) and halimane (4) structural types havebeen isolated from the bark of Croton eluteria Bennet, commonly known as cascarilla. Their structureshave been fully characterized by spectroscopic means. Cascarilla extract and its major component,cascarillin, were found to significantly increase histamine-induced gastric acid secretion in the mousestomach. These preliminary results provide the first rationale for the use of cascarilla in bitterpreparations aimed at improving digestion. Keywords: Cascarilla; Croton eluteria; diterpenes; halimane; clerodanes; gastric secretion, digestiveliqueurs
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