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| - Angiotensin Converting Enzyme Inhibitory Activity inCommercial Fermented Products. Formation of Peptides underSimulated Gastrointestinal Digestion
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| - The angiotensin converting enzyme (ACE)-inhibitory activity of several commercial fermented milkswas evaluated. Most of these products showed moderate inhibitory activity, but a few exceptionswere detected. The high ACE-inhibitory activity found in some cases could be related to the origin ofthe milk. Two of these products were subjected to an enzymatic hydrolysis process, which simulatesphysiological digestion, to study the influence of digestion on ACE-inhibitory activity. The activity didnot significantly change or increase during simulated gastrointestinal digestion. The peptides generatedfrom one selected product during simulated digestion were sequenced by tandem spectrometry. Mostpeptides found at the end of the simulated digestion were released after 30 min of incubation withthe pancreatic extract. This suggests that physiological digestion promotes the formation of activepeptides from the proteins present in these fermented products. The potential ACE-inhibitory activityof the identified peptides is discussed with regard to their amino acid sequences. Keywords: ACE-inhibitory activity; peptides, fermented milk products; simulated gastrointestinaldigestion; mass spectrometry
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