| Abstract
| - The work investigates the possibility of the protective action of kaempferol on phosphatidylcholineliposome membranes exposed to the pro-oxidative action of diphenyltin dichloride (DPhT) andtriphenyltin chloride (TPhT) induced by UV radiation (λ = 253.7 nm). The concentrations of kaempferoland its equimolar mixtures with DPhT and TPhT were determined so that they induce 50% inhibitionin oxidation of liposomes irradiated with UV. They are 11.6, 10.0, and 4.5 μM/L, which constitute thefollowing sequence of antioxidative activity: kaempferol/triphenyltin > kaempferol/diphenyltin >kaempferol. This relationship is confirmed by the results on the antiradical ability of kaempferol andits mixtures with DPhT and TPhT toward the free radical 2,2-diphenyl-1-picrylhydrazyl. Similarsequences obtained in both studies suggest a possible mechanism of the antiradical action of themixtures as free radical scavengers. Kaempferol's ability, then documented, to form complexes withphenyltins indicates (a) a possible way to liquidate the peroxidation caused by the free radical formsof phenyltins and (b) the stabilizing role of chelating in the antioxidative action of the kaempferol/phenyltins. The differentiation in the action of the compounds studied may, among others, resultfrom different localizations in the liposome membrane, which is indicated by the results of thefluorometric studies. Keywords: Kaempferol; phenyltin; antioxidants; complexes; fluidity; liposomes
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