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| - Flavones Suppress the Expression of the High-Affinity IgEReceptor FcεRI in Human Basophilic KU812 Cells
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| - We examined the effect of flavones on the expression of the high-affinity IgE receptor FcεRI, whichplays a central role in the IgE-mediated allergic response. Flow cytometric analysis showed that theflavones chrysin and apigenin were able to reduce the cell surface expression of FcεRI in humanbasophilic KU812 cells. Immunoblot analysis revealed that the total cellular expression of the FcεRIα and γ chains decreased upon treatment with chrysin and apigenin. Moreover, the level of mRNAexpression of the FcεRI α and γ chains also decreased when the cells were cultured with the twoflavones. Previously, we demonstrated that the reduction of extracellular signal-regulated kinase1/2(ERK1/2) phosphorylation was involved in the downregulation of FcεRI expression. The two flavoneswere shown to reduce the level of ERK1/2 phosphorylation. These results suggested that chrysinand apigenin have the ability to downregulate FcεRI expression and this suppressive effect may bedue to the reduction of ERK1/2 phosphorylation. Keywords: Chrysin; apigenin; basophil; KU812; FcεRI; ERK1/2
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