Abstract
| - The aim of this study was to evaluate the effects of dietary Kazunoko (salted herring roe) lipids,which contain large amounts of cholesterol, phosphatidylcholine, and n-3 polyunsaturated fatty acids,such as eicosapentaenoic acid (EPA, 20:5n-3) and docosahexaenoic acid (DHA, 22:6n-3), on lipidand glucose metabolism in mice. Male Crlj:CD-1 (ICR) mice were fed one of four experimental dietswhich contained 6% lard, 1% Kazunoko lipids + 5% lard, 3% Kazunoko lipids + 3% lard, and 6%Kazunoko lipids for 12 weeks. Plasma total cholesterol, triacylglycerol, phospholipid, and glucoseconcentrations were significantly lower in the 3% and 6% Kazunoko lipid diet groups than in lard and1% Kazunoko lipid diet groups (p< 0.05). Plasma adiponectin concentrations of mice fed the 6%Kazunoko lipid diet were higher than those of animals fed the lard diet group. These results suggestthat EPA and DHA rather than cholesterol in the Kazunoko lipids influence the plasma total cholesterollevel. The constituent Kazunoko lipids may not only decrease the levels of plasma lipids but alsodecrease glucose concentrations by enhancing plasma adiponectin levels in mice. Keywords: Kazunoko; n-3 polyunsaturated fatty acid; cholesterol; plasma lipids; plasma glucose;insulin; adiponectin
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