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| - Monomers of Condensed Tannins Affect theLarval Exsheathment of Parasitic Nematodes of Ruminants
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| - The current control of parasitic nematodes in small ruminants relies on the use of chemical anthelmintics, but the development of resistance requires research in alternatives. Bioactive plants representone of those solutions. Previous results suggest that plants rich in condensed tannins (CTs) mighthave direct anthelmintic effects. However, the relationships between the biochemistry of activecompounds and the mechanisms of action remain to be elucidated. Therefore, this study examinedin vitro the effects of different CT monomers on the exsheathment of infective larvae for two nematodespecies. Monomers of prodelphinidins were more potent inhibitors of exsheathment than those ofprocyanidins. More severe inhibition was also found with galloyl derivatives. These results suggestthat the number of free hydroxy groups of CT monomers is a key factor in interactions with parasitelarvae. Comparison of effects between the two nematodes suggests different susceptibility to monomers depending on species, which might be related to the protein composition of sheaths. Keywords: Nutraceutical; parasitic nematode; flavan-3-ols; condensed tannins; larval exsheathment;Haemonchus contortus; Trichostrongylus colubriformis; prodelphinidins; procyanidins
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