| Abstract
| - Starting from nonpeptide agonists and antagonists of human urotensin-II (hU-II), several pharmacophoreswere designed and compared to the structure of hU-II. NMR and dynamic studies were realized on hU-IIand urotensin-II-related peptide to check the conformation flexibilities of these peptides and the relationshipsbetween their potential 3D structures and the pharmacophores. In parallel, a virtual screening was carriedout, leading to the discovery of six new derivatives with micromolar affinities. This last result shows theinterest of these pharmacophores for the discovery of new ligands.
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