| Abstract
| - A method is presented for the automated preparation of schematic diagrams for protein−ligand complexes,in which the ligand is displayed in conventional 2D form, and the interactions to and between the residuesin its vicinity are summarized in a concise and information-rich manner. The structural entities are arrangedto maximize aesthetic ideals and to properly convey important distance relationships. The diagram is annotatedwith calculated hydrogen bonds, a substitution contour, solvent exposure, chelated metals, covalently boundlinkages, π−π and π−cation interactions, and, for series of complexes, conserved residues and interactions.Residues, cofactors, ions, and solvent components are drawn in cartoon form as adjuncts to the ligand. Themethod can be applied to aligned sets which contain multiple ligands, or multiple members of a proteinfamily, in which case the ligand orientations and protein residue placement will show consistent trendsthroughout the series.
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