| Attributs | Valeurs |
|---|
| type
| |
| Is Part Of
| |
| Subject
| |
| Title
| - Protein Surface Conservation in Binding Sites
|
| has manifestation of work
| |
| related by
| |
| Author
| |
| Abstract
| - An algorithm is described which uses the conservation of the 3D structure of protein surfaces, as opposed to their sequences, to detect protein−protein binding sites. The protein in which protein−protein binding sites are sought is compared with structures of multiple structurally related proteins and the surface that is conserved at least once is considered to be a part of the binding site. The binding site predictions obtained in this way for a set of protein−protein complexes correspond well with the actual protein−protein binding sites. A comparison of this method with an algorithm using the support vector machine approach for predicting protein−protein binding sites shows structural conservation to be an important characteristic that distinguishes binding sites from the remainder of protein surfaces.
|
| Alternative Title
| - Protein Surface Conservation
|
| is part of this journal
| |
