| Abstract
| - Starting from 1H,3H-thiazolo[3,4-a]benzimidazoles (TBZs), we performed the design, synthesis,and the structure−activity relationship studies of a series of 2,3-diaryl-1,3-thiazolidin-4-ones.Some derivatives proved to be highly effective in inhibiting HIV-1 replication at nanomolarconcentrations with minimal cytotoxicity, thereby acting as nonnucleoside HIV-1 RT inhibitors(NNRTIs). Computational studies were used to delineate the ligand-RT interactions and toprobe the binding of the ligands to HIV-1 RT.
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