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Synthesis and Biological Activity of the Superestrogen(E)-17-Oximino-3-O-sulfamoyl-1,3,5(10)-estratriene: X-ray Crystal Structure of(E)-17-Oximino-3-hydroxy-1,3,5(10)-estratriene
Synthesis and Evaluation of 2-Amino-9-(1,3-dihydroxy-2-propoxymethyl)-6-fluoropurine Mono- and Diesters as Potential Prodrugs of Ganciclovir
2,6-Difluorophenol as a Bioisostere of a Carboxylic Acid: BioisostericAnalogues of γ-Aminobutyric Acid
Preparation and Characterization of Noveltrans-[PtCl2(amine)(isopropylamine)] Compounds: Cytotoxic Activity andApoptosis Induction in ras-Transformed Cells
Synthesis and Pharmacological Evaluation of Some8-Cyanopyrido[3‘,2‘:4,5]thieno[3,2-d]triazine Derivatives as Inhibitors ofNitric Oxide and Eicosanoid Biosynthesis
Synthesis and Biological Evaluation of the First N-Alkyl Cage Dimeric4-Aryl-1,4-dihydropyridines as Novel Nonpeptidic HIV-1 Protease Inhibitors
Thieno[3,2-b]- and Thieno[2,3-b]pyrrole Bioisosteric Analogues of theHallucinogen and Serotonin Agonist N,N-Dimethyltryptamine
Synthesis and Antimalarial Activity of 11 Dispiro-1,2,4,5-tetraoxane Analoguesof WR 148999. 7,8,15,16-Tetraoxadispiro[5.2.5.2]hexadecanes Substituted at the 1and 10 Positions with Unsaturated and Polar Functional Groups
Quinolones: Novel Probes in Antifilarial Chemotheraphy,
Probes for Narcotic Receptor-Mediated Phenomena. 27. Synthesis andPharmacological Evaluation of Selective δ-Opioid Receptor Agonists from4-[(αR)-α-(2S,5R)-4-Substituted-2,5-dimethyl-1-piperazinyl-3-methoxybenzyl]-N,N-diethylbenzamides and Their Enantiomers
QSAR Based on Biological Microcalorimetry
New Selective and Potent 5-HT1B/1D Antagonists: Chemistry andPharmacological Evaluation of N-Piperazinylphenyl Biphenylcarboxamides andBiphenylsulfonamides
Conformational Analysis of a Glycosylated Human Myelin OligodendrocyteGlycoprotein Peptide Epitope Able To Detect Antibody Response in MultipleSclerosis
Synthesis and Evaluation of Oxodioxolenylmethyl Carbamate Prodrugs ofPseudomycins
5,6-Diphenylpyridazine Derivatives as Acyl-CoA:Cholesterol AcyltransferaseInhibitors
Design and Synthesis of Non-peptidic Inhibitors for the Syk C-Terminal SH2Domain Based on Structure-Based In-Silico Screening
Solid-Phase Synthesis and Inhibitory Effects of Some Pyrido[1,2-c]pyrimidineDerivatives on Leukocyte Functions and Experimental Inflammation
Synthesis and Antiviral Activity of New Anti-HIV Amprenavir Bioisosteres
Characterization of Orally Active Nonpeptide Vasopressin V2 Receptor Agonist.Synthesis and Biological Evaluation of Both the (5R)- and (5S)-Enantioisomersof 2-[1-(2-Chloro-4-pyrrolidin-1-yl-benzoyl)-2,3,4,5-tetrahydro-1H-1-benzazepin-5-yl]-N-isopropylacetamide
Spectral and Crystallographic Study of Pyridinic Analogues of Nimesulide:Determination of the Active Form of Methanesulfonamides as COX-2 SelectiveInhibitors
Synthesis, Antitumor Activity, Molecular Modeling, and DNA BindingProperties of a New Series of Imidazonaphthalimides
Structure−Activity Relationships for Pyrido-, Imidazo-, Pyrazolo-, Pyrazino-,and Pyrrolophenazinecarboxamides as Topoisomerase-Targeted AnticancerAgents
Molecular Basis of the Antitumor Activities of2-Crotonyloxymethyl-2-cycloalkenones
Distorting Malaria Peptide Backbone Structure to Enable Fitting into MHCClass II Molecules Renders Modified Peptides Immunogenic and Protective
New Potential Uroselective NO-Donor α1-Antagonists
Total Synthesis and Anti-Tubulin Activity of Epi-C3 Analogues ofCryptophycin-24
Design, Synthesis, and Biological Evaluation of2,4-Diamino-5-methyl-6-substituted-pyrrolo[2,3-d]pyrimidines as DihydrofolateReductase Inhibitors
Interaction between an Amantadine Analogue and the Transmembrane Portionof the Influenza A M2 Protein in Liposomes Probed by 1H NMR Spectroscopy ofthe Ligand
Synthesis of N3,5‘-Cyclo-4-(β-d-ribofuranosyl)-vic-triazolo[4,5-b]pyridin-5-one, aNovel Compound with Anti-Hepatitis C Virus Activity
Anticancer and Antimalarial Efficacy and Safety of Artemisinin-DerivedTrioxane Dimers in Rodents
Structural and Energetic Analyses of the Effects of the K103N Mutation ofHIV-1 Reverse Transcriptase on Efavirenz Analogues
Design, Synthesis, and Biological Evaluation of Hybrid Molecules Containingα-Methylene-γ-Butyrolactones and α-Bromoacryloyl Moieties
Structure of a Synthetic Fragment of the LALF Protein When Bound toLipopolysaccharide
Discovery of Novel Quinoline-Based Estrogen Receptor Ligands Using PeptideInteraction Profiling
Antimalarial and Antiplasmodial Activities of Norneolignans. Syntheses and SAR
3-Hydroxy-2-(5-hydroxypentyl)-4H-chromen-4-one: A Bidentate or Tridentate Iron(III)Ligand?
Hydroxy-1,2,5-oxadiazolyl Moiety as Bioisoster of the Carboxy Function. Synthesis, IonizationConstants, and Pharmacological Characterization of γ-Aminobutyric Acid (GABA) RelatedCompounds
Novel Methylenephosphophosphonate Analogues of Mycophenolic Adenine Dinucleotide.Inhibition of Inosine Monophosphate Dehydrogenase
Synthesis and Evaluation of [18F] Labeled Pyrimidine Nucleosides for Positron EmissionTomography Imaging of Herpes Simplex Virus 1 Thymidine Kinase Gene Expression
Structural Basis for the Structure−Activity Relationships of Peroxisome Proliferator-ActivatedReceptor Agonists
Common Pharmacophores for Uncharged Human Ether-a-go-go-Related Gene (hERG) Blockers
Novel Heterobivalent Tacrine Derivatives as Cholinesterase Inhibitors with Notable SelectivityToward Butyrylcholinesterase
Microwave-Accelerated Synthesis of P1‘-Extended HIV-1 Protease Inhibitors Encompassing aTertiary Alcohol in the Transition-State Mimicking Scaffold
Synthesis and Biological Activity of a Gemcitabine Phosphoramidate Prodrug
Isatin Sulfonamide Analogs Containing a Michael Addition Acceptor: A New Class of Caspase3/7 Inhibitors
4-[ω-[4-Arylpiperazin-1-yl]alkoxy]phenyl)imidazo[1,2-a]pyridine Derivatives: FluorescentHigh-Affinity Dopamine D3 Receptor Ligands as Potential Probes for Receptor Visualization
Development of Novel Enkephalin Analogues that Have Enhanced Opioid Activities at Both μand δ Opioid Receptors
3-Substituted 7-Phenyl-Pyrroloquinolinones Show Potent Cytotoxic Activity in Human CancerCell Lines
Poorly Soluble Marketed Drugs Display Solvation Limited Solubility
Design and Development of Water-Soluble Curcumin Conjugates as Potential AnticancerAgents
Synthesis, Affinity Profile, and Functional Activity of Muscarinic Antagonists with a1-Methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine Structure
Ovarian Cancer Activity of Cyclic Amine and Thiaether Metal Complexes
Design, Synthesis, and Evaluation of the Antiproliferative Activity of a Series of Novel FusedXanthenone Aminoderivatives in Human Breast Cancer Cells
Synthesis and in Vitro Antiprotozoal Activities of Water-Soluble, Inexpensive 3,7-Bis(dialkylamino)phenoxazin-5-ium Derivatives
Design, Synthesis, and Antihepatocellular Carcinoma Activity of Nitric Oxide Releasing Derivatives of Oleanolic Acid
Novel Ligands Rationally Designed for Characterizing I2−Imidazoline Binding Sites Nature and Functions
Determination of log D via Automated Microfluidic Liquid−Liquid Extraction
Multiple and Single Binding Modes of Fragment-Like Kinase Inhibitors Revealed by Molecular Modeling, Residue Type-Selective Protonation, and Nuclear Overhauser Effects
Synthesis and Evaluation of Novel Boron-Containing Complexes of Potential Use for the Selective Treatment of Malignant Melanoma
Rational Design and Synthesis of 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications
Lipopeptide with a RGDK Tetrapeptide Sequence Can Selectively Target Genes to Proangiogenic α5β1 Integrin Receptor and Mouse Tumor Vasculature
Synthesis and Pharmacological Characterization at Glutamate Receptors of the Four Enantiopure Isomers of Tricholomic Acid
Paclitaxel Derivatives for Targeted Therapy of Cancer: Toward theDevelopment of Smart Taxanes
Melatonergic Properties of the (+)- and (−)-Enantiomers ofN-(4-Methoxy-2,3-dihydro-1H-phenalen-2-yl)amide Derivatives
6-Aminoquinolones as New Potential Anti-HIV Agents
Photochemical Synthesis of N-Arylbenzophenanthridine Selective EstrogenReceptor Modulators (SERMs)
Coumarins Derivatives as Dual Inhibitors of Acetylcholinesterase andMonoamine Oxidase
Methylene−gem-Difluorocyclopropane Analogues of Nucleosides: Synthesis,Cyclopropene−Methylenecyclopropane Rearrangement, and Biological Activity
Synthesis and Biological Evaluation of a New Furo[2,3-h]quinolin-2(1H)-one
Inhibition of Human Immunodeficiency Virus Reverse Transcriptase bySynadenol Triphosphate and Its E-Isomer
Evaluation of Lactam-Bridged Neurotensin Analogues Adjusting ψ(Pro10) Closeto the Experimentally Derived Bioactive Conformation of NT(8−13)
New Steroidal Dimers with Antifungal and Antiproliferative Activity
Effect of a 6-Cyano Substituent in 14-Oxygenated N-Methylmorphinans onOpioid Receptor Binding and Antinociceptive Potency
Mechanisms of Cytotoxicity of Selected Organogold(III) Compounds
Synthesis of Two 3,5-Disubstituted Sulfonamide Catechol Ligands andEvaluation of Their Iron(III) Complexes for Use as MRI Contrast Agents
Design and Synthesis of N-[(4-Methoxyphenoxy)carbonyl]-N-[[4-[2-(5-methyl-2-phenyl-4-oxazolyl)ethoxy]phenyl]methyl]glycine [Muraglitazar/BMS-298585], a Novel Peroxisome Proliferator-Activated Receptor α/γ DualAgonist with Efficacious Glucose and Lipid-Lowering Activities
Synthesis and Antibacterial Activity of the 4-Quinolone-3-carboxylic AcidDerivatives Having a Trifluoromethyl Group as a Novel N-1 Substituent
Lead Optimization Providing a Series of Flavone Derivatives as Potent Nonsteroidal Inhibitorsof the Cytochrome P450 Aromatase Enzyme
Replacement of the N-terminal Tyrosine Residue in Opioid Peptides with3-(2,6-Dimethyl-4-carbamoylphenyl)propanoic Acid (Dcp) Results in Novel Opioid Antagonists
Design, Synthesis, and Incorporation of a β-Turn Mimetic in Angiotensin II Forming NovelPseudopeptides with Affinity for AT1 and AT2 Receptors
Design, Synthesis, and Biological Activity of Novel Polycyclic Aza-Amide FKBP12 Ligands
Structural Analogues of Smoothened Intracellular Loops as Potent Inhibitors of HedgehogPathway and Cancer Cell Growth
β- and γ-Di- and Tripeptides as Potential Substrates for the Oligopeptide Transporter hPepT1
A Swift All-Atom Energy-Based Computational Protocol to Predict DNA−Ligand BindingAffinity and ΔTm
Synthesis and Evaluation of [2-(4-Quinolyloxy)phenyl]methanone Derivatives: Novel Selective Inhibitors of Transforming Growth Factor-β Kinase
New Chimeric Antimalarials with 4-Aminoquinoline Moiety Linked to a Tetraoxane Skeleton
Synthesis, Cytotoxicity, and Anti-Trypanosoma cruzi Activity of New Chalcones
N-Substituted 3-Acetyltetramic Acid Derivatives as Antibacterial Agents
Conversion of a Highly Selective Sigma-1 Receptor-Ligand to Sigma-2 Receptor Preferring Ligands with Anticocaine Activity
Molecular Characterization of Macbecin as an Hsp90 Inhibitor
Synthesis of Novel Phenserine-Based-Selective Inhibitors ofButyrylcholinesterase for Alzheimer's Disease
Thioamides: Synthesis, Stability, and Immunological Activities ofThioanalogues of Imreg. Preparation of New Thioacylating Agents UsingFluorobenzimidazolone Derivatives
Combined Effect of Platination and Intercalation upon DNA Binding of NovelCytotoxic Pt−Bis(naphthalimide) Complexes
Synthesis of Apicidin-Derived Quinolone Derivatives: Parasite-SelectiveHistone Deacetylase Inhibitors and Antiproliferative Agents
Crystal Structure of the Hydrated Strontium Salt of Methotrexate: TwoIndependent Molecules with Different Conformations
New Pyridoquinoline Derivatives as Potential Inhibitors of theFluoroquinolone Efflux Pump in Resistant Enterobacter aerogenes Strains
Aldisine Alkaloids from the Philippine Sponge Stylissa massa Are PotentInhibitors of Mitogen-Activated Protein Kinase Kinase-1 (MEK-1)
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