Documentation scienceplus.abes.fr version Bêta

À propos de : Total Synthesis and Anti-Tubulin Activity of Epi-C3 Analogues ofCryptophycin-24        

AttributsValeurs
type
Is Part Of
Subject
Title
  • Total Synthesis and Anti-Tubulin Activity of Epi-C3 Analogues ofCryptophycin-24
has manifestation of work
related by
Author
Abstract
  • Epi-C3-cryptophycin-24, epi-C3-m-chlorobenzyl-cryptophycin-24, and the corresponding styreneswere synthesized and tested in vitro against the MCF-7 and multidrug-resistant MCF-7/ADRbreast cancer cell lines and in an in vitro tubulin assembly assay. The results demonstratethat the S configuration at the C3 stereocenter is not required to induce potent cytotoxicityand the m-Cl substituent present on the C10 side chain did not induce any large change inactivity.
article type
is part of this journal



Alternative Linked Data Documents: ODE     Content Formats:       RDF       ODATA       Microdata