| Abstract
| - The conserved, nonantigenic, nonimmunogenic malaria Merozoite Surface Protein-2 peptide1, having high affinity for red blood cells, was rendered immunogenic and protective in Aotusmonkeys by specifically changing some critical residues. The NMR structure revealed a switchfrom classical type III‘ into distorted III‘ and III β turns in the protective peptides. These changesmay lead to a better fit into the Aotus MHC class II human HLA-DRβ1* 12 molecule equivalent,thus activating the immune system.
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