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À propos de : Synthesis and Characterization of theNovel Fluorescent Prolyl OligopeptidaseInhibitor 4-Fluoresceinthiocarbamoyl-6-aminocaproyl-l-prolyl-2(S)-(Hydroxy-acetyl)pyrrolidine        

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  • Synthesis and Characterization of theNovel Fluorescent Prolyl OligopeptidaseInhibitor 4-Fluoresceinthiocarbamoyl-6-aminocaproyl-l-prolyl-2(S)-(Hydroxy-acetyl)pyrrolidine
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  • The synthesis and characterization of the firstfluorescent prolyl oligopeptidase inhibitor 4-fluoresceinthiocarbamoyl-6-aminocaproyl-l-prolyl-2(S)-(hydroxyacetyl)pyrrolidine is described. This compound has an IC50 value of 0.83nM and a dissociation half-life of 160 min, and its fluorescencesignal is detectable using standard filters for fluorescein. Theseproperties make this compound a suitable probe for visualizingprolyl oligopeptidase in various applications.
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