Documentation scienceplus.abes.fr version Bêta

À propos de : 7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine: AFunctionally Selective γ-AminobutyricAcidA (GABAA) α2/α3-Subtype SelectiveAgonist That Exhibits Potent AnxiolyticActivity but Is Not Sedating in AnimalModels        

AttributsValeurs
type
Is Part Of
Subject
Title
  • 7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine: AFunctionally Selective γ-AminobutyricAcidA (GABAA) α2/α3-Subtype SelectiveAgonist That Exhibits Potent AnxiolyticActivity but Is Not Sedating in AnimalModels
has manifestation of work
related by
Author
Abstract
  • There is increasing evidence that compounds withselectivity for γ-aminobutyric acidA (GABAA) α2- and/or α3-subtypes may retain the desirable anxiolytic activity ofnonselective benzodiazepines but possess an improved sideeffect profile. Herein we describe a novel series of GABAA α2/α3 subtype-selective agonists leading to the identification ofthe development candidate 17, a nonsedating anxiolytic inpreclinical animal assays.
article type
is part of this journal



Alternative Linked Data Documents: ODE     Content Formats:       RDF       ODATA       Microdata