| Abstract
| - In vitro evaluation of the novel cycloalkyl-N-(4-chlorophenyl)-hydroxamic acids (2a−g)demonstrated that 2b,d,e exhibited rather marked inhibitory activity (IC50 = 7−10 μM) againstpancreatic carcinoma, 2b−d against colon carcinoma, 2d against laryngeal carcinoma, and2b,d against breast carcinoma. 2e showed the most pronounced anti-cytomegalovirus activity(EC50 = 1.5 and 0.8 μg mL-1) only at ≥5-fold lower than the cytotoxic concentration. 2d and 2fshowed modest, albeit selective, activity against cytomegalovirus (2d, EC50 = 7.3−8.9 μg mL-1,selectivity index 7−10; 2f, EC50 = 7−13 μg mL-1, selectivity index 10).
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