| Abstract
| - We have identified a small interfering RNA(siRNA) motif, consisting entirely of 2‘-O-methyl and 2‘-fluoronucleotides, that displays enhanced plasma stability andincreased in vitro potency. At one site, this motif showedremarkable >500-fold improvement in potency over the unmodified siRNA. This marks the first report of such a potentfully modified motif, which may represent a useful design fortherapeutic oligonucleotides.
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