| Abstract
| - We describe herein the development of novel huperzine A−tacrine hybrids characterized by 3-methylbicyclo[3.3.1]non-3-ene scaffolds. These compounds were specifically designed to establish tight interactions, throughdifferent binding modes, with the midgorge recognition sites of human acetylcholinesterase (hAChE: Y72,D74) and human butyrylcholinesterase (hBuChE: N68, D70) and their catalytic or peripheral sites.Compounds 5a−c show a markedly improved biological profile relative to tacrine and huperzine A.
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