| Abstract
| - A series of N,N‘-bisbenzylidenebenzene-1,4-diamine and N,N‘-bisbenzylidenenaphthalene-1,4-diaminederivatives were synthesized as inhibitors for human sirtuin type 2 (SIRT2). The design of the new compoundswas based on two earlier reported hits from molecular modeling and virtual screening. The most potentcompound was N,N‘-bis(2-hydroxybenzylidene)benzene-1,4-diamine, which was equipotent with the mostpotent hit compound and well-known SIRT2 inhibitor sirtinol.
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