| Abstract
| - Synthesis and biological activity of a novel class of quaternary ammonium salt muscarinic M3 receptorantagonists, showing high selectivity versus the M2 receptor, are described. Selected compounds exhibitedpotent anticholinergic properties, in isolated guinea-pig trachea, and good functional selectivity for tracheaover atria. In vivo, the same compounds potently inhibited acetylcholine-induced bronchoconstriction afterintratracheal administration in the guinea pig.
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