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À propos de : Solid-Phase Synthesis of an A−B Loop Mimetic of the Cε3 Domainof Human IgE: Macrocyclization by Sonogashira Coupling        

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  • Solid-Phase Synthesis of an A−B Loop Mimetic of the Cε3 Domainof Human IgE: Macrocyclization by Sonogashira Coupling
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  • The solid-phase synthesis of a cyclic peptide containing the 21-residue epitope found in the A−Bloop of the Cε3 domain of human immunoglobulin E has been carried out. The key macrocyclizationstep to form the 65-membered ring is achieved in ∼15% yield via an “on-resin” Sonogashira couplingreaction which concomitantly installs a diphenylacetylene amino acid conformational constraintwithin the loop.
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