An enantioselective synthetic method for α-alkylserines bythe phase-transfer catalytic alkylation of 2-phenyl-2-oxazoline-4-carbonylcamphorsultam (4a) was developed. The phase-transfer catalytic α-alkylation of 4a using P2-Et at −78 °Cgave α-alkylation (75∼99%, 90∼97% de), which could beeasily hydrolyzed to α-alkylserines.
