| Abstract
| - Flavin coenzymes play a variety of roles in biological systems. This Perspective highlights the chemicalversatility of flavins by reviewing research on five flavoenzymes that have been studied in our laboratory.Each of the enzymes discussed in this review [the acyl-CoA dehydrogenases (ACDs), CDP-6-deoxy-l-threo-d-glycero-4-hexulose-3-dehydrase reductase (E3), CDP-4-aceto-3,6-dideoxygalactose synthase(YerE), UDP-galactopyranose mutase (UGM), and type II isopentenyl diphosphate:dimethylallyldiphosphate isomerase (IDI-2)] utilizes flavin in a distinct role. In particular, the catalytic mechanismsof two of these enzymes, UGM and IDI-2, may involve novel flavin chemistry.
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