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| - Diffusion Coefficient and the Secondary Structure of Poly-l-glutamic Acid in AqueousSolution
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| - The diffusion coefficients (D) of poly-l-glutamic acid (PLG) at various pHs are investigated by the laser-induced transient-grating method with a new photoreactive probe molecule. The pH dependence of D iscompared with that of the helical content of PLG measured by circular dichroism. It is found that the pHdependences of both quantities are very similar. Since the frictions of the translational diffusion of chargedand protonated carboxyl groups are found to be similar each other, it is concluded that the conformation ofthe main polymer chain is the main factor in determining the diffusion process; in other words, the α-helixconformation makes the molecular diffusion faster. This result indicates that the conformational change of aprotein can be detected by monitoring the diffusion coefficient.
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