| Abstract
| - Background. Familial Mediterranean fever (FMF) is an autosomal recessive hereditary disease which is characterized by recurrent attacks of fever and peritonitis, pleuritis, arthritis, or erysipelas-like skin disease.There are very limited study in the literature about mean platelet volume (MPV) levels in FMF patients. Objectives. We aimed to investigate levels of mean MPV during attack period and attack free periods in Familial Mediterranean fever (FMF) patients and to compare with healthy controls. Methods. The study consisted of 16 FMF patients during an attack, 51 FMF patients in attack-free period and 75 healthy controls. Erythrocyte sedimentation rate, C-reactive protein, white blood cell count, platelet count, and MPV levels were retrospectively recorded from patient files. Results. At the end of the study statistical analyses showed that MPV was significantly lower in FMF patients both during attack and attack-free than in healthy controls (p=0.015, p=0.016); however, there was no difference among during attack and attack-free patients (p=0.279). All results were shown in Table 1. Table 1Group of healthy controlsGroup of attack-freeGroup of during attachPβP$P£n=75n=51n=16 rSex (F/M, % )56/19 (75/25)38/13 (75/25)10/6 (63/37)0.7810.9980.781Age (year)33±831±1131±110.7910.2200.294platelet (×103/L)276±67283±70324±790.0740.0570.016MPV (fL)8.3±0.837.9±0.947.7±1.060.2790.0160.015hemoglobin (g/dl)14.1±1.0613.9±1.2714.0±1.450.9240.6570.735WBC (±103/μL)8.4±1.87.8±2.09.8±2.70.0070.0140.077CRP (mg/L)-3.2±2.021.2±21.90.0001--ESR (mm/s)-8.4±6.420±120.0001-- Conclusions. We found that the MPV levels were significantly lower in the FMF group than in healthy controls. Our results suggest that patients with FMF have not an increased platelet activation. It was conculed that the lower MPV levels were an expected result of secondary thrombocytosis in FMF patients. Disclosure of Interest. None Declared
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