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| - CHEMICAL STIMULUS DETERMINANTS OF CAT GENICULATE GANGLION CHEMORESPONSIVE GROUP I UNIT DISCHARGE
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| - Cat geniculate ganglion group I neurons preferentially innervate receptors on fungiform papillae on the reai and sides of the tongue with fibers of large diameter. They display low spontaneous activity rates and are responsive to distilled water and many inorganic acids. In a study testing a wide variety of organic compounds, it was found that group I units were discharged by compounds with carboxylic and phosphoric acid groups. A few nitrogen compounds were also effective. In all cases the response was pH dependent in that maximum discharge occurred when the solution pH was at or below the pKa of the active chemical group. The compounds most active in the pH region 5.0−7.0 proved to be nitrogen heterocyclic compounds (pyridine or thiazolidine) or compounds with a heterocyclic nitrogen component (imidazole ring). Only the proton donor form of the molecule seemed to stimulate.
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