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Design Challenges for Hemoproteins: The Solution Structure ofApocytochrome b5,
Electron Paramagnetic Resonance Spectroscopy of the Heme Domain of InducibleNitric Oxide Synthase: Binding of Ligands at the Arginine Site Induces Changes inthe Heme Ligation Geometry
Calcium Modulation of Bovine Photoreceptor Guanylate Cyclase
Systematic Relationship between Phospholipase A2 Activity and Dynamic LipidBilayer Microheterogeneity
Fhit, a Putative Tumor Suppressor in Humans, Is a Dinucleoside5‘,5‘ ‘‘-P1,P3-Triphosphate Hydrolase
Site-Directed Cleavage of DNA by a Linker Histone−Fe(II) EDTA Conjugate: Localization of a Globular Domain Binding Site within a Nucleosome
Structural Changes in the Peptide Backbone in Complex Formation betweenActivated Rhodopsin and Transducin Studied by FTIR Spectroscopy
Solution Structure of the Immunodominant Region of Protein G of BovineRespiratory Syncytial Virus,
GrpE Accelerates Nucleotide Exchange of the Molecular Chaperone DnaK with anAssociative Displacement Mechanism
Femtosecond Transient Absorption Study of Carotenoid to Chlorophyll EnergyTransfer in the Light-Harvesting Complex II of Photosystem II
Stathmin: A Tubulin-Sequestering Protein Which Forms a Ternary T2S Complexwith Two Tubulin Molecules
The Structure of the Superantigen Exfoliative Toxin A Suggests a Novel Regulationas a Serine Protease,
Mapping the Promoter DNA Sites Proximal to Conserved Regions of σ70 in anEscherichia coli RNA Polymerase−lacUV5 Open Promoter Complex
Mapping Protein−Protein Interactions with a Library of Tethered Cutting Reagents: The Binding Site of σ70 on Escherichia coli RNA Polymerase
Structural Basis of Electron Transfer Modulation in the Purple CuA Center
Ser/Thr Protein Phosphatase Type 5 (PP5) Is a Negative Regulator ofGlucocorticoid Receptor-Mediated Growth Arrest
The Spasmodic Peptide Defines a New Conotoxin Superfamily
Probing Inhibitors Binding to Human Urokinase Crystals by Raman Microscopy: Implications for Compound Screening
Conformational Dimorphism and Transmembrane Orientation of Prion ProteinResidues 110−136 in Bicelles
Absolute Measurement of Phosphorylation Levels in a Biological Membrane UsingAtomic Force Microscopy: The Creation of Phosphorylation Maps
Crystal Structure of Fucose-Specific Lectin from Aleuria aurantia Binding Ligandsat Three of Its Five Sugar Recognition Sites,
A Spring-Loaded State of NusG in Its Functional Cycle Is Suggested by X-rayCrystallography and Supported by Site-Directed Mutants
Ornithine Cyclodeaminase: Structure, Mechanism of Action, and Implications forthe μ-Crystallin Family,
Analysis of the Role of Intraprotein Electron Transfer in Photoreactivation by DNAPhotolyase in Vivo
Crystal Structure of the Broadly Cross-Reactive HIV-1-Neutralizing Fab X5 andFine Mapping of Its Epitope,
Oxidative Metabolites Accelerate Alzheimer's Amyloidogenesis by a Two-StepMechanism, Eliminating the Requirement for Nucleation
Crystal Structure of a Luteoviral RNA Pseudoknot and Model for a MinimalRibosomal Frameshifting Motif,
A Manganese(IV)/Iron(IV) Intermediate in Assembly of the Manganese(IV)/Iron(III)Cofactor of Chlamydia trachomatis Ribonucleotide Reductase
Structure of KCNE1 and Implications for How It Modulates the KCNQ1 Potassium Channel
Mechanism of Direct Coupling between Binding and Induced Structural Change inRegulatory Calcium Binding Proteins
Detection of an EPR Multiline Signal for the S0* State in Photosystem II
Enhancing the Activity of Protein C by Mutagenesis To Improve theMembrane-Binding Site: Studies Related to Proline-10
Construction of a Novel Redox Protein by Rational Design: Conversion of aDisulfide Bridge into a Mononuclear Iron−Sulfur Center
Resonance Raman Characterization of Soluble Guanylate Cyclase Expressed fromBaculovirus
New Light on Allostery: Dynamic Resonance Raman Spectroscopy of HemoglobinKempsey
Carotenoid Oxidation in Photosystem II
Structural Basis of Cleavage by RNase H of Hybrids of Arabinonucleic Acids andRNA,
Structural Similarities between MutT and the C-Terminal Domain of MutY
Domains I and III of the Human Copper Chaperone for Superoxide DismutaseInteract via a Cysteine-Bridged Dicopper(I) Cluster
Structural Constraints Imposed by a Non-Native Disulfide Cause ReversibleChanges in Rhodopsin Photointermediate Kinetics
Hanging Gondola Structure of the T1 Domain in a Voltage-Gated K+ Channel
Phosphodiesterase A1, a Regulator of Cellulose Synthesis in Acetobacter xylinum,Is a Heme-Based Sensor
Five Coplanar Anion Binding Sites on One Face of Phospholipase A2: Relationshipto Interface Binding,
HIV-1 gp41 Six-Helix Bundle Formation Occurs Rapidly after the Engagement ofgp120 by CXCR4 in the HIV-1 Env-Mediated Fusion Process
Inhibitor “Double Occupancy” in the Qo Pocket of the Chloroplast Cytochrome b6fComplex
Visual Detection of Specific, Native Interactions between Soluble andMicrobead-Tethered α-Helices from Membrane Proteins
Tyrosine D Oxidation at Cryogenic Temperature in Photosystem II
S-Methylated Cysteines in Human Lens γS-Crystallins
The Hydantoin Lesions Formed from Oxidation of 7,8-Dihydro-8-oxoguanine ArePotent Sources of Replication Errors in Vivo
Specific Non-Native Hydrophobic Interactions in a Hidden Folding Intermediate: Implications for Protein Folding
The 2.15 Å Crystal Structure of Mycobacterium tuberculosis Chorismate MutaseReveals an Unexpected Gene Duplication and Suggests a Role in Host−PathogenInteractions
3‘-Phosphoadenosine-5‘-phosphosulfate Reductase in Complex with Thioredoxin: A Structural Snapshot in the Catalytic Cycle,
Binding Energy in the One-Electron Reductive Cleavage of S-Adenosylmethioninein Lysine 2,3-Aminomutase, a Radical SAM Enzyme
Structural Transitions of the RING1B C-Terminal Region upon Binding the Polycomb cbox Domain
Branched Activation- and Catalysis-Specific Pathways for Electron Relay to the Manganese/Iron Cofactor in Ribonucleotide Reductase from Chlamydia trachomatis
Detection of a C4a-Hydroperoxyflavin Intermediate in the Reaction of a Flavoprotein Oxidase
Proline Pipe Helix: Structure of the Tus Proline Repeat Determined by 1H NMR
Solution NMR Evidence That the HIV-1 Protease Catalytic Aspartyl Groups HaveDifferent Ionization States in the Complex Formed with the Asymmetric DrugKNI-272
The CD4 Determinant for Downregulation by HIV-1 Nef Directly Binds to Nef.Mapping of the Nef Binding Surface by NMR
Ras-Dependent Activation of Fibroblast Mitogen-Activated Protein Kinase by5-HT1A Receptor via a G Protein βγ-Subunit-Initiated Pathway
Cytidine Deaminase Complexed to 3-Deazacytidine: A “Valence Buffer” in ZincEnzyme Catalysis
Erythromycin Biosynthesis: Kinetic Studies on a Fully Active Modular PolyketideSynthase Using Natural and Unnatural Substrates
Design of Heterotetrameric Coiled Coils: Evidence for Increased Stabilization byGlu-−Lys+ Ion Pair Interactions
The Activating Dual Phosphorylation of MAPK by MEK Is Nonprocessive
Orientational Distribution of α-Helices in the Colicin B and E1 Channel Domains: A One and Two Dimensional 15N Solid-State NMR Investigation in UniaxiallyAligned Phospholipid Bilayers
HIV-1 Protease Inhibitors Are Substrates for the MDR1 Multidrug Transporter
DNA Cassette Exchange in ES Cells Mediated by FLP Recombinase: An EfficientStrategy for Repeated Modification of Tagged Loci by Marker-Free Constructs
Ultrafast Carotenoid Band Shifts Probe Structure and Dynamics in PhotosyntheticAntenna Complexes
Direct Measurement of Small Ligand-Induced Conformational Changes in theAspartate Chemoreceptor Using EPR
Crystal Structure of Tyrosine Hydroxylase with Bound Cofactor Analogue and Ironat 2.3 Å Resolution: Self-Hydroxylation of Phe300 and the Pterin-Binding Site,
Binding of Etoposide to Topoisomerase II in the Absence of DNA: DecreasedAffinity as a Mechanism of Drug Resistance
Effect of Protein Hydration on Receptor Conformation: Decreased Levels of BoundWater Promote Metarhodopsin II Formation
Potassium and Sodium Binding to the Outer Mouth of the K+ Channel
Small Molecular Products of Dealkylation in Soman-Inhibited Electric EelAcetylcholinesterase
Identification of a Guanylyl Cyclase-Activating Protein-Binding Site within theCatalytic Domain of Retinal Guanylyl Cyclase1
Engineering a Thermostable Protein via Optimization of Charge−ChargeInteractions on the Protein Surface
Does the Structure of the Water-Oxidizing Photosystem II−Manganese Complex atRoom Temperature Differ from Its Low-Temperature Structure? A ComparativeX-ray Absorption Study
Chemical Activity of Cholesterol in Membranes
Contribution of Enzyme−Phosphoribosyl Contacts to Catalysis by Orotidine5‘-Phosphate Decarboxylase
The Catalytic Center in Nitrous Oxide Reductase, CuZ, Is a Copper−SulfideCluster
Identification of a Mn−O−Mn Cluster Vibrational Mode of the Oxygen-EvolvingComplex in Photosystem II by Low-Frequency FTIR Spectroscopy
Subsite Specificity of Memapsin 2 (β-Secretase): Implications for Inhibitor Design
Bacteria-Selective Synergism between the Antimicrobial Peptides α-HelicalMagainin 2 and Cyclic β-Sheet Tachyplesin I: Toward Cocktail Therapy
Effect of ErbB2 Coexpression on the Kinetic Interactions of Epidermal GrowthFactor with Its Receptor in Intact Cells
Molecular Crowding Accelerates Fibrillization of α-Synuclein: Could an Increasein the Cytoplasmic Protein Concentration Induce Parkinson's Disease?
Formation of a Trypsin−Borate−4-Aminobutanol Ternary Complex
The GAAA Tetraloop−Receptor Interaction Contributes Differentially to FoldingThermodynamics and Kinetics for the P4−P6 RNA Domain
Vibrational Spectroscopy Favors a Unique QB Binding Site at the Proximal Positionin Wild-Type Reaction Centers and in the Pro-L209 → Tyr Mutant fromRhodobacter sphaeroides
Primary Reactions of the LOV2 Domain of Phototropin, a Plant Blue-LightPhotoreceptor
Structure of Frataxin Iron Cores: An X-ray Absorption Spectroscopic Study
Evidence that Folding of an RNA Tetraloop Hairpin Is Less Cooperative than ItsDNA Counterpart
The Antimalarial Drug Resistance Protein Plasmodium falciparum ChloroquineResistance Transporter Binds Chloroquine
Heme A Synthase Does Not Incorporate Molecular Oxygen into the Formyl Groupof Heme A
A Definitive Mechanism for Chorismate Mutase
Out-of-Shape DNA Minor Groove Binders: Induced Fit Interactions of HeterocyclicDications with the DNA Minor Groove
Guanine Nucleotide Exchange Factors Operate by a Simple AllostericCompetitive Mechanism
On the Seeding and Oligomerization of pGlu-Amyloid Peptides (in vitro)
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