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Meta-analysis: Many factors affect mortality from community-acquired pneumonia
Review: Noninvasive tests are useful only for symptomatic deep venous thrombosis
Review: C-reactive protein has moderate diagnostic accuracy for serious bacterial infection in children with fever
Confirming the value of pulse oximetry screening for diagnosing critical congenital heart disease
Smoking, age, and laryngeal height predicted obstructive airway disease in adults
Review: CT angiography and magnetic resonance imaging are the best less invasive tests for renal artery stenosis
The Alcohol Use Disorders Identification Test was not affected by ethnic and sex bias
The Severity of Dependence Scale had high sensitivity and specificity for detecting benzodiazepine dependence
The Quick PsychoDiagnostics Panel was accurate for identifying psychiatric disorders in primary care
Middelheim Frontality Score may be useful for differentiating between Alzheimer’s disease and frontotemporal dementia
The 3 item anxiety subscale of the Edinburgh Postpartum Depression Scale may detect postnatal depression as well as the 10 item full scale
14C-urea breath test and Giemsa stain were sensitive for detecting Helicobacter pylori
D-dimer levels detected DVT in patients hospitalized for stroke rehabilitation
Review: non-psychiatric physicians have low accuracy for recognising depression in their patients
Specific clinical findings, including coma, neck stiffness and seizures, increase the likelihood of haemorrhagic stroke, but no combination of features is definitively diagnostic
Review: the physical examination can exclude the diagnosis of meningitis in low-risk adults
Abdominal palpation had moderate sensitivity and specificity for detecting abdominal aortic aneurysm
The Hopkins Verbal Learning Test had high sensitivity and good specificity for detecting mild dementia in older adults
The WHO-5 Wellbeing index performed the best in screening for depression in primary care
Review: a low clinical probability plus a normal D-dimer test result excludes a diagnosis of deep venous thrombosis
Review: tissue transglutaminase test is almost as accurate as endomysial antibody test for diagnosis of coeliac disease
The Even Briefer Assessment Scale for Depression in German was accurate for identifying depression in elderly patients
RBANS has reasonable test-retest reliability in schizophrenia
The Anxiety Change Expectancy Scale score shows high internal validity and correlation with validated measures of anxiety, self-esteem, and hopelessness in varied settings
Can we predict vesicoureteric reflux?
Review: Chest radiography lacks utility for detecting left ventricular dysfunction
Accuracy of ECG interpretation in primary care was limited for detecting atrial fibrillation
Prospective studies show that magnetic resonance angiography has high sensitivity and specificity for clinically relevant arterial steno-occlusions in adults with peripheral arterial disease symptoms
High-sensitivity troponin useful for diagnosis and prognosis in patients with acute coronary syndrome
Review: screening tests are not as accurate as overnight polysomnography for the diagnosis of adult sleep apnoea
A normal alveolar dead space fraction plus d-dimer assay ruled out suspected pulmonary embolism in the emergency department
Review: questionnaires for detecting clinical depression in primary care have similar diagnostic accuracy
Children’s drawings of headache pain were accurate for diagnosing migraine
The Ottawa ankle rules have a high sensitivity for excluding fractures of the ankle and midfoot in acute ankle sprain
A 3 item screening instrument had moderate sensitivity and specificity for detecting migraine headaches
Neurological examination identified 61% of patients with focal cerebral hemisphere lesions but without obvious focal signs
Review: history and physical examination can accurately identify migraine and the need for neuroimaging in patients with headache
2 of 3 dimensional rating scales were useful for discriminating anxiety and depression in adolescents
The Patient Health Questionnaire 2-item is a rapid, sensitive and specific screening tool for identifying adolescents with major depression
D-dimer testing and impedance plethysmography were effective for the exclusion of deep venous thrombosis
Review: Subtle clinical findings can detect left-sided heart failure in adults
Review: Clinical assessment is inaccurate for diagnosing community-acquired pneumonia
Review: Clinical features and electrocardiographic changes predict myocardial infarction in adults with chest pain
Meta-analysis finds screening for prostate cancer with PSA does not reduce prostate cancer-related or all-cause mortality but results likely due to heterogeneity - the two highest quality studies identified do find prostate cancer-related mortality reductions
A negative d-dimer test result alone or combined with low risk clinical status effectively ruled out symptomatic DVT
Review: newer technologies improve sensitivity in detecting uterine cervical lesions but at a substantially increased cost
The Mini Cog had high sensitivity and specificity for diagnosing dementia in community dwelling older adults
Combining fasting plasma glucose and glycosylated haemoglobin improved the accuracy for detecting patients with diabetes
Review: transvaginal ultrasonography, sonohysterography, and hysteroscopy have moderate accuracy in abnormal uterine bleeding
Chest radiographs and BNP levels provided complementary information beyond clinical findings for diagnosing heart failure
Review: point of care dipstick urinalysis has low accuracy for detecting proteinuria in pregnancy
Third and fourth heart sounds had low sensitivity but moderate to high specificity for predicting left ventricular dysfunction.
Chinese version of the Edinburgh Postnatal Depression Scale was useful for detecting postnatal depression
Review: strong evidence recommends genetic and metabolic testing in subgroups of children with autism
The Screening Tool for Autism in Two Year Olds can identify children at risk of autism
Conners’ Teacher Rating Scale has limited ability to predict DSM-IV ADHD in referred schoolchildren
Paediatric clinical decision support systems
Clinical assessment plus ultrasonography accurately predicted deep venous thrombosis
Pulse oximetry and the WHO algorithm were appropriate for identifying acute lower respiratory tract infection in Peruvian children
Mammography reduces breast cancer mortality in women aged 39-69 years; but harms may outweigh benefits in women under 50
Computed tomography pneumocolon had a low sensitivity for detecting colorectal neoplasms
Review: ELISA D-dimer is sensitive but not specific in diagnosing pulmonary embolism in an ambulatory clinical setting
Conventional cervical smears were better than monolayer cytology or human papillomavirus testing for detecting cervical intraepithelial neoplasia
Review: important bedside predictors are patient’s description of chest pain for CAD and electrocardiography for MI
Review: no single physical examination sign rules in or out osteoporosis or spinal fracture
Review: IgA endomyseal and transglutaminase antibodies had high specificity for diagnosis of coeliac disease
Review: self report of hearing loss and the whispered voice test are useful for screening for hearing impairment
Meta-analysis: Pursuing compensation after closed-head injury slows recovery
Mini-Mental State Examination and the Informant Questionnaire on Cognitive Decline were efficient screening tests for dementia
Review: Positive test results identify early colorectal cancer and save lives
Skin examinations by primary care clinicians were highly specific but had low sensitivity for the detection of skin cancer
Serial ECGs were more sensitive than an initial ECG for diagnosing chest pain
The office-based blood agar plate culture was more sensitive than the rapid antigen detection test for detecting pharyngitis
Hammering the point home: serologic testing costs more and harms more patients than other strategies for the diagnosis of active tuberculosis in India
Number needed to screen to detect adenomas, advanced adenomas and colorectal cancer is higher in women than in similarly aged men
Review: mydriatic retinal photography is the most effective test for detecting diabetic retinopathy
Magnetic resonance direct thrombus imaging was accurate in suspected deep venous thrombosis
Review: the Ottawa knee rule accurately rules out knee fractures and can substantially reduce the need for x rays in patients with acute knee injuries
Clinical examination had poor sensitivity for detecting non-cephalic presentation in late pregnancy
Adding a question that asks whether help is wanted improves sensitivity of a depression screening tool
Fits, faints, or fatal fantasy? Fabricated seizures and child abuse
Meta-analysis: Duplex ultrasonography is accurate for most peripheral arterial occlusive disease in legs
2 questions were as good as more questions for detecting depression
Genotype testing improved the clinical diagnosis of Alzheimer disease
Short scales were as effective as long scales in screening for depression in older patients
B-natriuretic peptide concentrations had high sensitivity and specificity for detecting abnormal ventricular function
Review: computed tomographic colonography is accurate for medium and large colorectal polyps and cancer
Review: clinical examination is often as accurate as magnetic resonance imaging for diagnosing meniscus tears
Inclusion of informant ratings of cognitive difficulties improves the accuracy of the MMSE in predicting Alzheimer’s disease
Albumin measurements in a random urine sample accurately screened microalbuminuria and macroalbuminuria in NIDDM
Review: A prediction guide that includes clinical assessment and noninvasive tests is accurate for diagnosing deep venous thrombosis
Ottawa ankle rules identified fractures of the ankle and midfoot and could reduce the use of radiography by one third
Review: anti-cyclic citrullinated peptide antibody is a more specific test for rheumatoid arthritis than rheumatoid factor
Point-of-care D-dimer tests can contribute to patient management in outpatients with suspected venous thromboembolism, particularly those at low risk
Serious pathology in people presenting to primary care with acute low back pain is rare (0.9%), but high false-positive rates for some ‘red flags’ may limit their diagnostic value
Ultrasound scan for suspected appendicitis in children: risk of diagnostic inaccuracy increases with BMI at or above 85th percentile and clinical probability of appendicitis of 50% or lower
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