Meta-analysis finds screening for prostate cancer with PSA does not reduce prostate cancer-related or all-cause mortality but results likely due to heterogeneity - the two highest quality studies identified do find prostate cancer-related mortality reductions
Commentary on: DjulbegovicMBeythRJNeubergerMM. Screening for prostate cancer: systematic review and meta-analysis of randomised controlled trials. BMJ2010;341:c4543.