| Abstract
| - The present study examines the ability of isoflavone extracts from whole soy bread and two soybread fractions, crumb and crust, to modulate the proliferation of human prostate cancer PC-3 cells.Total isoflavone content in the two fractions of soy bread were similar (3.17 μmol/g dry basis). However,their conjugate patterns were altered. Both fractions of soy bread contained a similar level of isoflavoneaglycones (∼24%). Low concentrations of soy bread extracts increased PC-3 cell proliferation asmuch as 47% compared to untreated control. This proliferative effect in cell growth was reduced athigher extract concentration. Soy bread crust extract (10 mg/mL) reduced PC-3 cell proliferation by15% compared to untreated control. Interestingly, wheat bread extracts increased cell proliferationat all concentrations tested. Although extracts from both breads possessed biological activity, onlysoy bread crust extract reduced PC-3 cell proliferation. This observation may be related to the presenceof soy in this bread. Keywords: Soy bread; isoflavones; cancer cell proliferation
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