| Abstract
| - The ingestion of complex foodstuff implicates the simultaneous presence along the digestive tract ofseveral antioxidants micronutrients. This work aimed to determine if the interactions that may occurat the digestive level between polyphenols and other antioxidant micronutrients may modulate thefate of polyphenols in the splanchnic area. This study was conducted in a rat in situ intestinal perfusionmodel. Polyphenols (gallic and caffeic acids, catechin, and naringenin) were perfused with or withoutan antioxidant cocktail. For gallic acid, a significant reduction (−20%) of its net transfer through thebrush border associated with a drastic decrease of its intestinal secretion of conjugates (−90%) wasobserved. By contrast, the transfer of catechin through the brush border increased (18%) and thesecretion of its conjugates was twice in the presence of the antioxidants. Perfused polyphenols largelydiffered in their respective biliary secretion, but these fluxes were not modified by the presence ofthe antioxidant cocktail. Finally, the simultaneous presence in the small intestine of polyphenols andother dietary antioxidants never affects polyphenol splanchnic metabolism but may modify theirintestinal transport without noticeable consequence on their final availability for peripheral tissues. Keywords: Antioxidants; polyphenols; association; absorption; splanchnic metabolism
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