| Abstract
| - 6-Methoxygossypol and 6,6′-dimethoxygossypol were recently isolated from the root tissue of cotton plants. Together with gossypol, these natural products were investigated for a wide range of bioactivities. Antioxidant effects, the potential to prevent DNA damage, anticancer activity, and antitrypanosomal effects were studied. The 6-methoxygossypol generally exhibited equal bioactivities to the 6,6′-dimethoxygossypol, but gossypol showed greater activities than both methylated derivatives in scavenging free radicals, reducing ferric ions, and preventing UV-induced DNA damage. All three compounds inhibited the growth of cervical (SiHa), breast (MCF-7), and colon (Caco-2) cancer cells. At ≥5 ppm of test concentrations, 6,6′-dimethoxygossypol showed a stronger ability than gossypol to inhibit the growth of Trypanosoma brucei cells.
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